21853-11-2

21853-11-2 structure

Name: 5α-Pregnane-3β,6α-diol-20-one
Chemical Name: 5α-Pregnane-3β,6α-diol-20-one
CAS Number: 21853-11-2
Molecular Formula: C₂₁H₃₄O₃
Molecular Weight: 334.49
Catalog: Research Areas Cancer
Create Date: 2018-04-21 03:35:26
Modify Date: 2024-01-04 12:34:02
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

Name	5α-Pregnane-3β,6α-diol-20-one

Description	5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Steroids
In Vitro	Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].
References	[1]. Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. [2]. de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191.