443103-97-7

443103-97-7 structure

Name: A2A receptor antagonist 1
Chemical Name: A2A receptor antagonist 1
CAS Number: 443103-97-7
Molecular Formula: C₁₆H₁₂FN₅O
Molecular Weight: 309.3
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-02-25 03:26:19
Modify Date: 2025-08-25 16:25:15
A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.

Name	A2A receptor antagonist 1

Description	A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cancer Research Areas >> Neurological Disease
Target	Ki: 4 nM (adenosine A2A receptor), 264 nM (A1 receptor)[1]
References	[1]. Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9.