Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S,R,S)-AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl)
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Purity: 95.0%
Stocking Period: 10 Day
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1835705-55-9

1835705-55-9 structure

1835705-55-9 structure

Name: E3 ligase Ligand-Linker Conjugates 8
Chemical Name: E3 ligase Ligand-Linker Conjugates 8
CAS Number: 1835705-55-9
Molecular Formula: C₃₈H₅₉ClN₄O₇S
Molecular Weight: 751.42
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2018-02-18 16:36:09
Modify Date: 2024-01-16 14:50:59
E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 8

Description	E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 8 uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 8 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
References	[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

Molecular Formula	C₃₈H₅₉ClN₄O₇S
Molecular Weight	751.42