1835705-55-9
1835705-55-9 structure
- Name: E3 ligase Ligand-Linker Conjugates 8
- Chemical Name: E3 ligase Ligand-Linker Conjugates 8
- CAS Number: 1835705-55-9
- Molecular Formula: C38H59ClN4O7S
- Molecular Weight: 751.42
- Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
- Create Date: 2018-02-18 16:36:09
- Modify Date: 2025-08-22 19:10:11
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E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
| Name | E3 ligase Ligand-Linker Conjugates 8 |
|---|
| Description | E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|---|---|
| Related Catalog | |
| Target |
E3 Ligase Ligand-Linker Conjugate[1] |
| In Vitro | E3 ligase Ligand-Linker Conjugates 8 uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 8 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2]. |
| References |
[1]. US 20170121321 A1 |
| Molecular Formula | C38H59ClN4O7S |
|---|---|
| Molecular Weight | 751.42 |