1185136-22-4

1185136-22-4 structure

Name: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamidehydrochloride
Chemical Name: 6-[4-(2-Biphenylyl)-1-piperazinyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)hexanamide hydrochloride (1:1)
CAS Number: 1185136-22-4
Molecular Formula: C₃₂H₄₀ClN₃O
Molecular Weight: 518.133
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-19 11:33:58
Modify Date: 2024-03-02 20:16:38
LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1].

Name	6-[4-(2-Biphenylyl)-1-piperazinyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)hexanamide hydrochloride (1:1)
Synonyms	1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1) 6-[4-(Biphenyl-2-yl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrochloride (1:1) 6-[4-(2-Biphenylyl)-1-piperazinyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)hexanamide hydrochloride (1:1)

Description	LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT7 Receptor:0.13 nM (IC50) 5-HT1A Receptor:60.9 nM (IC50) 5-HT2A Receptor:1464 nM (IC50)
References	[1]. Marcello Leopoldo, et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50(17):4214-21.