156467-85-5
156467-85-5 structure
- Name: α-Conotoxin Im-I
- Chemical Name: [(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-4,27-Bis(3-carbamimidamidopropyl)-24-carbamoyl-40-(glycylamino)-16-(hydroxymethyl)-30-(1H-indol-3-ylmethyl)-33-methyl-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decaazatricyclo[17.16.7.07,11]dotetracont-13-yl]acetic acid
- CAS Number: 156467-85-5
- Molecular Formula: C52H78N20O15S4
- Molecular Weight: 1351.561
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2018-07-20 08:41:35
- Modify Date: 2025-08-25 17:50:16
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α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].
| Name | [(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-4,27-Bis(3-carbamimidamidopropyl)-24-carbamoyl-40-(glycylamino)-16-(hydroxymethyl)-30-(1H-indol-3-ylmethyl)-33-methyl-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decaazatricyclo[17.16.7.07,11]dotetracont-13-yl]acetic acid |
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| Synonyms |
[(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-4,27-Bis(3-carbamimidamidopropyl)-24-carbamoyl-40-(glycylamino)-16-(hydroxymethyl)-30-(1H-indol-3-ylmethyl)-33-methyl-3,6,12,15,18,26,29,32,35,41-decaoxo-21 ;,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decaazatricyclo[17.16.7.07,11]dotetracont-13-yl]acetic acid
23,6-(Iminopropanodithiomethano)-1H,22H-pyrrolo[2,1-v][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclodotriacontine-29-acetic acid, 37-[(2-aminoacetyl)amino]-18-(aminocarbonyl)-3,15-bis[3-[(aminoiminomethyl)amino]propyl]triacontahydro-26-(hydroxymethyl)-12-(1H-indol-3-ylmethyl)-9-methyl-1,4,7,10,13,16,24,27,30,36-decaoxo-, (3S,6R,9S,12S,15S,18R,23R,26S,29S,34aS,37R)- |
| Description | α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2]. |
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| Related Catalog | |
| Target |
α7/α9 nAChR[1][2]. |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Molecular Formula | C52H78N20O15S4 |
| Molecular Weight | 1351.561 |
| Exact Mass | 1350.483887 |
| LogP | -7.80 |
| Index of Refraction | 1.770 |