893556-85-9

893556-85-9 structure

Name: PF 945863
Chemical Name: (3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
CAS Number: 893556-85-9
Molecular Formula: C₄₄H₆₅N₅O₁₀
Molecular Weight: 824.014
Catalog: Research Areas Infection
Create Date: 2018-06-14 10:09:28
Modify Date: 2024-01-10 20:58:55
PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].

Name	(3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
Synonyms	2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-( ;dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R)- (3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3] ;oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside

Description	PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	PF-945863 is an orally active macrolide antibiotic[2].
References	[1]. Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38(8):1322-1327. [2]. Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52(23):7446-7457.