253771-21-0

253771-21-0 structure

Name: AR-C102222
Chemical Name: 5-[(4'-Amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride (1:1)
CAS Number: 253771-21-0
Molecular Formula: C₁₉H₁₇ClF₂N₆O
Molecular Weight: 418.828
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-07-11 17:05:34
Modify Date: 2025-09-05 18:41:53
AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain[1].

Name	5-[(4'-Amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride (1:1)
Synonyms	2-Pyridinecarbonitrile, 5-[(4'-amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinazolin]-1-yl)carbonyl]-, hydrochloride (1:1) 5-[(4'-Amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride (1:1)

Description	AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
References	[1]. Chris Walpole, et al. Diastereoselective synthesis of fluorinated piperidine quinazoline spirocycles as iNOS selective inhibitors. Tetrahedron Letters. Volume 53, Issue 24, 13 June 2012, Pages 2942-2947.