444930-42-1

444930-42-1 structure

Name: PCNA I1
Chemical Name: N'-[(E)-(1-Hydroxy-2-naphthyl)methylene]-3-methyl-2-thiophenecarbohydrazide
CAS Number: 444930-42-1
Molecular Formula: C₁₇H₁₄N₂O₂S
Molecular Weight: 310.370
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-06-24 14:16:43
Modify Date: 2024-01-14 21:35:46
PCNA-I1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo[1].

Name	N'-[(E)-(1-Hydroxy-2-naphthyl)methylene]-3-methyl-2-thiophenecarbohydrazide
Synonyms	2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1E)-(1-hydroxy-2-naphthalenyl)methylene]hydrazide MFCD02606552 N'-[(E)-(1-Hydroxy-2-naphthyl)methylene]-3-methyl-2-thiophenecarbohydrazide N'-[(E)-(1-Hydroxy-2-naphthyl)methylene]-3-methylthiophene-2-carbohydrazide PCNA-I 1

Description	PCNA-I1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Tan Z, et al. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol Pharmacol. 2012 Jun;81(6):811-9.