128660-97-9

128660-97-9 structure
128660-97-9 structure
  • Name: THP-PEG4-OH
  • Chemical Name: 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
  • CAS Number: 128660-97-9
  • Molecular Formula: C13H26O6
  • Molecular Weight: 278.342
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-25 07:54:59
  • Modify Date: 2025-08-25 16:22:39
  • THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
Synonyms Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-
2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
Description THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.1±0.1 g/cm3
Boiling Point 394.0±42.0 °C at 760 mmHg
Molecular Formula C13H26O6
Molecular Weight 278.342
Flash Point 192.1±27.9 °C
Exact Mass 278.172943
LogP -1.46
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.467
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