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1355197-66-8

1355197-66-8 structure
1355197-66-8 structure
  • Name: Propargyl-PEG4-Boc
  • Chemical Name: 2-Methyl-2-propanyl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
  • CAS Number: 1355197-66-8
  • Molecular Formula: C16H28O6
  • Molecular Weight: 316.390
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-16 23:40:56
  • Modify Date: 2024-01-10 14:18:52
  • Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
Synonyms MFCD22683285
4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
Description Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.0±0.1 g/cm3
Boiling Point 380.3±32.0 °C at 760 mmHg
Molecular Formula C16H28O6
Molecular Weight 316.390
Flash Point 162.2±25.2 °C
Exact Mass 316.188599
LogP 0.89
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.454