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1807521-04-5

1807521-04-5 structure
1807521-04-5 structure
  • Name: Methylamino-PEG2-Boc
  • Chemical Name: 2-Methyl-2-propanyl 3-{2-[2-(methylamino)ethoxy]ethoxy}propanoate
  • CAS Number: 1807521-04-5
  • Molecular Formula: C12H25NO4
  • Molecular Weight: 247.331
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-07 11:09:31
  • Modify Date: 2024-01-11 21:54:46
  • Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl 3-{2-[2-(methylamino)ethoxy]ethoxy}propanoate
Synonyms 2-Methyl-2-propanyl 3-{2-[2-(methylamino)ethoxy]ethoxy}propanoate
Propanoic acid, 3-[2-[2-(methylamino)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD28155207
Description Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.0±0.1 g/cm3
Boiling Point 315.5±22.0 °C at 760 mmHg
Molecular Formula C12H25NO4
Molecular Weight 247.331
Flash Point 144.6±22.3 °C
Exact Mass 247.178360
LogP 0.79
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.441
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