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518044-36-5

518044-36-5 structure
518044-36-5 structure
  • Name: Mal-PEG4-Boc
  • Chemical Name: 2-Methyl-2-propanyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oate
  • CAS Number: 518044-36-5
  • Molecular Formula: C19H31NO8
  • Molecular Weight: 401.451
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-29 17:03:42
  • Modify Date: 2024-01-10 09:03:04
  • Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oate
Synonyms 2-Methyl-2-propanyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oate
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester
MFCD22683300
Description Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 499.9±40.0 °C at 760 mmHg
Molecular Formula C19H31NO8
Molecular Weight 401.451
Flash Point 256.1±27.3 °C
Exact Mass 401.204956
LogP 0.25
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.489