870640-64-5
870640-64-5 structure
- Name: (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate
- Chemical Name: 2-Methyl-2-propanyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methylheptanoate
- CAS Number: 870640-64-5
- Molecular Formula: C21H35NO3
- Molecular Weight: 349.508
- Catalog: Research Areas Cancer
- Create Date: 2018-07-14 19:29:54
- Modify Date: 2025-08-21 18:30:35
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Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
| Name | 2-Methyl-2-propanyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methylheptanoate |
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| Synonyms |
Heptanoic acid, 3-methoxy-5-methyl-4-[methyl(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3R,4S,5S)-
2-Methyl-2-propanyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methylheptanoate |
| Description | Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. |
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| Related Catalog | |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 426.3±35.0 °C at 760 mmHg |
| Molecular Formula | C21H35NO3 |
| Molecular Weight | 349.508 |
| Flash Point | 211.6±25.9 °C |
| Exact Mass | 349.261688 |
| LogP | 4.77 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.492 |