1146209-50-8
1146209-50-8 structure
- Name: MK-8267
- Chemical Name: 1-[(3R,4S)-3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-2,3-dihydro-3'H-spiro[chromene-4,2'-[1,3,4]thiadiazol]-3'-yl]ethanone
- CAS Number: 1146209-50-8
- Molecular Formula: C20H17F4N3O2S
- Molecular Weight: 439.427
- Create Date: 2018-07-07 16:24:10
- Modify Date: 2024-02-18 15:51:55
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MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
| Name | 1-[(3R,4S)-3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-2,3-dihydro-3'H-spiro[chromene-4,2'-[1,3,4]thiadiazol]-3'-yl]ethanone |
|---|---|
| Synonyms |
Ethanone, 1-[(3R,4S)-3-(2-aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-2,3-dihydrospiro[4H-1-benzopyran-4,2'(3'H)-[1,3,4]thiadiazol]-3'-yl]-
1-[(3R,4S)-3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-2,3-dihydro-3'H-spiro[chromene-4,2'-[1,3,4]thiadiazol]-3'-yl]ethanone MK-8267 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 545.2±60.0 °C at 760 mmHg |
| Molecular Formula | C20H17F4N3O2S |
| Molecular Weight | 439.427 |
| Flash Point | 283.5±32.9 °C |
| Exact Mass | 439.097748 |
| LogP | 3.32 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.640 |