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1432061-73-8

1432061-73-8 structure

1432061-73-8 structure

Name: Gabapentin-d6 hydrochloride
Chemical Name: [1-(Aminomethyl)(3,3,4,4,5,5-2H6)cyclohexyl]acetic acid hydrochloride (1:1)
CAS Number: 1432061-73-8
Molecular Formula: C₉H₁₂D₆ClNO₂
Molecular Weight: 213.73
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-06-28 01:54:47
Modify Date: 2026-07-01 15:12:13
Gabapentin-d6 (hydrochloride) is deuterium labeled Gabapentin (hydrochloride).

Name	[1-(Aminomethyl)(3,3,4,4,5,5-2H6)cyclohexyl]acetic acid hydrochloride (1:1)
Synonyms	Gabapentin Hydrochloride D6, D7 [D6 Major] [2H6]-Gabapentin HCl Cyclohexane-3,3,4,4,5,5-d6-acetic acid, 1-(aminomethyl)-, hydrochloride (1:1) D6-Gabapentin Hydrochloride XBUDZAQEMFGLEU-DWTYOMSA-N [2H6]-Gabapentin Hydrochloride Gabapentin hydrochloride salt [2H4]-Gabapentin hydrochloride Gabapentin HCl D6

Description	Gabapentin-d6 (hydrochloride) is deuterium labeled Gabapentin (hydrochloride).
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Receveur JM, et al. Synthesis and biological evaluation of conformationally restricted Gabapentin analogues. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2329-34. [3]. Parker DA, et al. Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices. Eur J Pharmacol. 2004 Jul 14;495(2-3):137-43. [4]. Stefani A, et al. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology. 1998;37(1):83-91. [5]. Lee BS, et al. Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain. J Korean Med Sci. 2013 Feb;28(2):308-14. [6]. Harden RN, et al. A Phase 2a, Randomized, Crossover Trial of Gabapentin Enacarbil for the Treatment of Postherpetic Neuralgia inGabapentin Inadequate Responders. Pain Med. 2013 Sep 18.

Molecular Formula	C₉H₁₂D₆ClNO₂
Molecular Weight	213.73
Exact Mass	213.140274

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