1345337-28-1

1345337-28-1 structure

Name: Tos-PEG9-Boc
Chemical Name: 2-Methyl-2-propanyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
CAS Number: 1345337-28-1
Molecular Formula: C₃₀H₅₂O₁₃S
Molecular Weight: 652.791
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-09 03:41:16
Modify Date: 2024-01-10 11:04:28
Tos-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-Methyl-2-propanyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
Synonyms	2-Methyl-2-propanyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

Description	Tos-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.