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1334172-70-1

1334172-70-1 structure
1334172-70-1 structure
  • Name: Lipoamido-PEG8-acid
  • Chemical Name: 33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
  • CAS Number: 1334172-70-1
  • Molecular Formula: C27H51NO11S2
  • Molecular Weight: 629.824
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-08 19:36:59
  • Modify Date: 2024-01-10 20:21:24
  • Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
Synonyms 33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
4,7,10,13,16,19,22,25-Octaoxa-28-azatritriacontan-1-oic acid, 33-(1,2-dithiolan-3-yl)-29-oxo-
Description Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 748.3±60.0 °C at 760 mmHg
Molecular Formula C27H51NO11S2
Molecular Weight 629.824
Flash Point 406.4±32.9 °C
Exact Mass 629.290344
LogP -1.15
Vapour Pressure 0.0±5.4 mmHg at 25°C
Index of Refraction 1.507