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1334177-96-6

1334177-96-6 structure
1334177-96-6 structure
  • Name: OPSS-PEG8-COOH
  • Chemical Name: 29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
  • CAS Number: 1334177-96-6
  • Molecular Formula: C27H46N2O11S2
  • Molecular Weight: 638.791
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-16 00:45:01
  • Modify Date: 2024-02-03 20:05:36
  • OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
Synonyms 29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontan-1-oic acid, 29-oxo-31-(2-pyridinyldithio)-
Description OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 768.5±60.0 °C at 760 mmHg
Molecular Formula C27H46N2O11S2
Molecular Weight 638.791
Flash Point 418.6±32.9 °C
Exact Mass 638.254272
LogP -0.80
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.541