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1347750-77-9

1347750-77-9 structure
1347750-77-9 structure
  • Name: Thiol-PEG6-acid
  • Chemical Name: 1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
  • CAS Number: 1347750-77-9
  • Molecular Formula: C15H30O8S
  • Molecular Weight: 370.459
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-09 11:56:53
  • Modify Date: 2024-02-29 19:16:12
  • Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
Synonyms 3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-mercapto-
MFCD26127814
1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
Description Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.1±0.1 g/cm3
Boiling Point 495.1±45.0 °C at 760 mmHg
Molecular Formula C15H30O8S
Molecular Weight 370.459
Flash Point 253.2±28.7 °C
Exact Mass 370.166138
LogP -1.37
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.478