1347750-77-9

1347750-77-9 structure

Name: Thiol-PEG6-acid
Chemical Name: 1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
CAS Number: 1347750-77-9
Molecular Formula: C₁₅H₃₀O₈S
Molecular Weight: 370.459
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-09 11:56:53
Modify Date: 2024-02-29 19:16:12
Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
Synonyms	3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-mercapto- MFCD26127814 1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

Description	Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.