1421933-37-0

1421933-37-0 structure

Name: Mal-PEG4-OH
Chemical Name: 1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione
CAS Number: 1421933-37-0
Molecular Formula: C₁₂H₁₉NO₆
Molecular Weight: 273.282
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-29 21:27:04
Modify Date: 2025-08-25 10:13:08
Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione
Synonyms	1-(2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}ethyl)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 1-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-

Description	Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562