159187-70-9

159187-70-9 structure

Name: MM 77 dihydrochloride
Chemical Name: 1-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2,5-pyrrolidinedione dihydrochloride
CAS Number: 159187-70-9
Molecular Formula: C₁₉H₂₉Cl₂N₃O₃
Molecular Weight: 418.358
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-08 23:53:18
Modify Date: 2025-08-25 21:58:47
MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity[1][2].

Name	1-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2,5-pyrrolidinedione dihydrochloride
Synonyms	2,5-Pyrrolidinedione, 1-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrochloride (1:2) 1-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}pyrrolidine-2,5-dione dihydrochloride 1-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2,5-pyrrolidinedione dihydrochloride

Description	MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1A Receptor
References	[1]. Briones-Aranda Alfredo, et al. Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. Eur J Pharmacol. 2005 Jan 31;508(1-3):155-8. [2]. Andrzej J Bojarski, et al. New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules. 2004 Feb 28;9(3):170-7.