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126433-07-6

126433-07-6 structure
126433-07-6 structure
  • Name: Tyrphostin 51
  • Chemical Name: (3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
  • CAS Number: 126433-07-6
  • Molecular Formula: C13H8N4O3
  • Molecular Weight: 268.228
  • Catalog: Signaling Pathways JAK/STAT Signaling EGFR
  • Create Date: 2018-07-10 22:25:25
  • Modify Date: 2024-01-13 18:07:49
  • Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].
Name (3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
Synonyms MFCD00133903
1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-
1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-
(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile
(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
Description Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].
Related Catalog
References

[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230.

[2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

Density 1.6±0.1 g/cm3
Boiling Point 788.2±60.0 °C at 760 mmHg
Molecular Formula C13H8N4O3
Molecular Weight 268.228
Flash Point 430.5±32.9 °C
Exact Mass 268.059631
LogP 0.04
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.757
Storage condition 2-8°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

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title: CAS No. 126433-07-6 | Chemsrc address: https://m.chemsrc.com/en/baike/1496028.html

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