147612-86-0

147612-86-0 structure

Name: H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH
Chemical Name: L-α-Glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-leucine
CAS Number: 147612-86-0
Molecular Formula: C₆₆H₉₇N₁₂O₂₄P
Molecular Weight: 1473.516
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2018-07-17 09:01:07
Modify Date: 2024-01-10 17:23:23
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].

Name	L-α-Glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-leucine
Synonyms	L-α-Glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-leucine L-Leucine, L-α-glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-

Description	EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
In Vitro	The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide)[1].
References	[1]. G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1(2):99-105. [2]. T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5(10):1313-23.