252870-46-5

252870-46-5 structure

Name: nAChR agonist 2
Chemical Name: (2S,4E)-N-Methyl-5-(3-pyridinyl)-4-penten-2-amine
CAS Number: 252870-46-5
Molecular Formula: C₁₁H₁₆N₂
Molecular Weight: 176.26
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2018-07-11 01:48:18
Modify Date: 2025-08-24 18:15:55
nAChR agonist 2 (compound 8) is a selective alpha4beta2 (α4β2) nAChR agonist (Kd=26 nM)[1].

Name	(2S,4E)-N-Methyl-5-(3-pyridinyl)-4-penten-2-amine
Synonyms	(2S,4E)-N-Methyl-5-(3-pyridinyl)-4-penten-2-amine 4-Penten-2-amine, N-methyl-5-(3-pyridinyl)-, (2S,4E)- nAChR agonist 2

Description	nAChR agonist 2 (compound 8) is a selective alpha4beta2 (α4β2) nAChR agonist (Kd=26 nM)[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Huang X, et al. Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions. J Med Chem. 2006;49(26):7661-7674.