1052076-77-3

1052076-77-3 structure

Name: Q94 hydrochloride
Chemical Name: 2-Benzyl-1-(4-chlorobenzyl)-1H-benzimidazole hydrochloride (1:1)
CAS Number: 1052076-77-3
Molecular Formula: C₂₁H₁₈Cl₂N₂
Molecular Weight: 369.29
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2018-07-06 04:19:16
Modify Date: 2024-01-02 15:56:50
Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].

Name	2-Benzyl-1-(4-chlorobenzyl)-1H-benzimidazole hydrochloride (1:1)
Synonyms	2-Benzyl-1-(4-chlorobenzyl)-1H-benzimidazole hydrochloride (1:1) 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(phenylmethyl)-, hydrochloride (1:1)

Description	Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Target	IC50: 916 nM (PAR1)[1].
References	[1]. Deng X, et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell. 2008 Jun;19(6):2520-33.