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136399-05-8

136399-05-8 structure
136399-05-8 structure
  • Name: Bromo-PEG6-alcohol
  • Chemical Name: 17-Bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol
  • CAS Number: 136399-05-8
  • Molecular Formula: C12H25BrO6
  • Molecular Weight: 345.227
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-28 02:09:53
  • Modify Date: 2024-01-02 20:02:11
  • Bromo-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 17-Bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol
Synonyms MFCD20926394
3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-bromo-
17-Bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol
Description Bromo-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.3±0.1 g/cm3
Boiling Point 404.9±40.0 °C at 760 mmHg
Molecular Formula C12H25BrO6
Molecular Weight 345.227
Flash Point 198.7±27.3 °C
Exact Mass 344.083435
LogP -1.25
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.474