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1858264-36-4

1858264-36-4 structure
1858264-36-4 structure
  • Name: Azido-PEG3-maleimide
  • Chemical Name: (1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid
  • CAS Number: 1858264-36-4
  • Molecular Formula: C15H23N5O6
  • Molecular Weight: 369.373
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-06-09 08:25:57
  • Modify Date: 2024-01-10 23:39:16
  • Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name (1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid
Synonyms (1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid
1H-Pyrrole-1-propanimidic acid, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-
Description Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Deshmukh AA, et al. Detection of Protease Activity by Fluorescent Peptide Zymography. J Vis Exp. 2019 Jan 20;(143).

[2]. Allo B, et al. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038.

Molecular Formula C15H23N5O6
Molecular Weight 369.373
Exact Mass 369.164825
LogP -0.60