212200-21-0

212200-21-0 structure

Name: MRS 1477
Chemical Name: Ethyl 4-ethyl-5-{[(2-methoxyethyl)sulfanyl]carbonyl}-6-methyl-2-phenyl-1,4-dihydro-3-pyridinecarboxylate
CAS Number: 212200-21-0
Molecular Formula: C₂₁H₂₇NO₄S
Molecular Weight: 389.51
Create Date: 2018-06-16 02:16:10
Modify Date: 2024-01-08 15:35:29
MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].

Name	Ethyl 4-ethyl-5-{[(2-methoxyethyl)sulfanyl]carbonyl}-6-methyl-2-phenyl-1,4-dihydro-3-pyridinecarboxylate
Synonyms	3-Pyridinecarboxylic acid, 4-ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-, ethyl ester Ethyl 4-ethyl-5-{[(2-methoxyethyl)sulfanyl]carbonyl}-6-methyl-2-phenyl-1,4-dihydro-3-pyridinecarboxylate

Description	MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer
In Vitro	MRS1477 在 MCF7 乳腺癌细胞中激发 Ca2+ 信号，但在原代乳腺上皮细胞中没有[1]。 MRS1477 (2 μM; 72 h) 与 capsaicine (10 μM) 一起诱导细胞凋亡并增加活性氧的产生和半胱天冬酶活性[1]。 MRS1477 (2 μM) 增加 capsaicine 诱发的 TRPV1 介导的电流密度水平[1]。
References	[1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950. [2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.