1446282-42-3

1446282-42-3 structure
1446282-42-3 structure
  • Name: Bis-PEG4-TFP ester
  • Chemical Name: Bis(2,3,5,6-tetrafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
  • CAS Number: 1446282-42-3
  • Molecular Formula: C24H22F8O8
  • Molecular Weight: 590.414
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-21 22:49:26
  • Modify Date: 2025-08-26 13:05:13
  • Bis-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Bis(2,3,5,6-tetrafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
Synonyms Bis(2,3,5,6-tetrafluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
4,7,10,13-Tetraoxahexadecane-1,16-dioic acid, bis(2,3,5,6-tetrafluorophenyl) ester
Description Bis-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density 1.4±0.1 g/cm3
Boiling Point 572.7±50.0 °C at 760 mmHg
Molecular Formula C24H22F8O8
Molecular Weight 590.414
Flash Point 289.0±25.0 °C
Exact Mass 590.118713
LogP 3.76
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.474
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