495076-64-7

495076-64-7 structure

Name: Org 25543 hydrochloride
Chemical Name: 4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1)
CAS Number: 495076-64-7
Molecular Formula: C₂₄H₃₃ClN₂O₄
Molecular Weight: 448.98
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2018-06-23 13:10:12
Modify Date: 2024-09-23 12:36:58
Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor (IC50: 16 nM). Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice[1][2][3].

Name	4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1)
Synonyms	4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1) Benzamide, N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)-, hydrochloride (1:1) MFCD23701926

Description	Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor (IC50: 16 nM). Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GlyT
References	[1]. Caulfield WL, et al. The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem. 2001 Aug 16;44(17):2679-82. [2]. Morita K, et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45. [3]. Mohammadzadeh A, et al. Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. Int J Mol Sci. 2021 Mar 1;22(5):2479.