51951-04-3

51951-04-3 structure

Name: Hydroxy-PEG2-CH2COOH
Chemical Name: [2-(2-Hydroxyethoxy)ethoxy]acetic acid
CAS Number: 51951-04-3
Molecular Formula: C₆H₁₂O₅
Molecular Weight: 164.156
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-20 17:06:44
Modify Date: 2024-01-20 09:53:33
Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	[2-(2-Hydroxyethoxy)ethoxy]acetic acid
Synonyms	[2-(2-Hydroxyethoxy)ethoxy]acetic acid MFCD20640451 Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-

Description	Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.