1185053-50-2
1185053-50-2 structure
- Name: Clozapine D8
- Chemical Name: 8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
- CAS Number: 1185053-50-2
- Molecular Formula: C18H11D8ClN4
- Molecular Weight: 334.873
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-06-26 11:28:01
- Modify Date: 2024-01-06 11:09:00
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Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4].
| Name | 8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine |
|---|---|
| Synonyms |
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)-
8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine |
| Description | Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4]. |
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| Related Catalog | |
| References |
[1]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 489.2±55.0 °C at 760 mmHg |
| Molecular Formula | C18H11D8ClN4 |
| Molecular Weight | 334.873 |
| Flash Point | 249.6±31.5 °C |
| Exact Mass | 334.180023 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.681 |
| Storage condition | -20°C |