1185053-50-2

1185053-50-2 structure

Name: Clozapine D8
Chemical Name: 8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
CAS Number: 1185053-50-2
Molecular Formula: C₁₈H₁₁D₈ClN₄
Molecular Weight: 334.873
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-26 11:28:01
Modify Date: 2024-01-06 11:09:00
Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4].

Name	8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
Synonyms	5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)- 8-Chloro-11-[4-methyl(2H8)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine

Description	Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. [2]. Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. [3]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. [4]. Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.