34218-80-9

34218-80-9 structure

Name: 2’-O-Methyl-4-thiouridine
Chemical Name: 1-(2-O-Methyl-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
CAS Number: 34218-80-9
Molecular Formula: C₁₀H₁₄N₂O₅S
Molecular Weight: 274.29
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-07-04 20:44:10
Modify Date: 2024-04-03 18:12:38
2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-(2-O-Methyl-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
Synonyms	1-(2-O-Methyl-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone 2(1H)-Pyrimidinone, 3,4-dihydro-1-(2-O-methyl-β-D-ribofuranosyl)-4-thioxo-

Description	2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.