957-86-8

957-86-8 structure

Name: pulcherriminic acid
Chemical Name: pulcherriminic acid
CAS Number: 957-86-8
Molecular Formula: C₁₂H₂₀N₂O₄
Molecular Weight: 256.29800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-07-14 19:09:50
Modify Date: 2024-01-06 16:05:24
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries[1][2].

Name	pulcherriminic acid
Synonyms	3,6-diisobutylpyrazine-2,5-diol 1,4-dioxide 1,5-dihydroxy-3,6-bis(2-methylpropyl)-4-oxidopyrazin-4-ium-2-one Pulcherriminic acid 2,5-Diisobutyl-3,6-dihydroxy-pyrazine-1,4-dioxide

Description	Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Pulcherriminic acid can inhibit the formation of Bacillus subtilis biofilm[2]. Pulcherriminic acid can form insoluble red pigment pulcherrimin in the presence of Fe3+ to compete for iron nutrients, thereby inhibiting the growth of Metschnikowia yeasts[3].
References	[1]. Siqi Yuan, et al. Research Progress of the Biosynthesis of Natural Bio-Antibacterial Agent Pulcherriminic Acid in Bacillus. Molecules. 2020 Nov 28;25(23):5611. [2]. Sofia Arnaouteli, et al. Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13553-13562 [3]. Vytautas Melvydas, et al. In vitro inhibition of Saccharomyces cerevisiae growth by Metschnikowia spp. triggered by fast removal of iron via two ways. Braz J Microbiol. 2020 Dec;51(4):1953-1964. doi: 10.1007/s42770-020-00357-3. Epub 2020 Aug 11.

HS Code	2933599090

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%