870281-17-7

870281-17-7 structure

Name: PI3Kδ-IN-15
Chemical Name: 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone
CAS Number: 870281-17-7
Molecular Formula: C₂₁H₁₆FN₇O
Molecular Weight: 401.40
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2018-06-28 21:50:00
Modify Date: 2024-01-19 19:14:30
PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].

Name	5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone
Synonyms	4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]- 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone

Description	PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	p110δ:0.5 nM (IC50) p110γ:15.3 nM (IC50) p110β:145 nM (IC50) p110α:152 nM (IC50)
References	[1]. Yeon Su Kim, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 1;45:116312.