875770-32-4

875770-32-4 structure

Name: Propargyl-PEG4-Tos
Chemical Name: 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate
CAS Number: 875770-32-4
Molecular Formula: C₁₈H₂₆O₇S
Molecular Weight: 386.460
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-13 20:28:49
Modify Date: 2025-09-25 17:17:47
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].

Name	3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate
Synonyms	3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 4-methylbenzenesulfonate 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate

Description	Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461. [2]. Senthilkumar T, et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled DrugDelivery, Release, and Imaging. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13114-13119.