1263047-17-1

1263047-17-1 structure

Name: Amino-PEG4-hydrazide-Boc
Chemical Name: 2-Methyl-2-propanyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate
CAS Number: 1263047-17-1
Molecular Formula: C₁₆H₃₃N₃O₇
Molecular Weight: 379.449
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-17 04:55:53
Modify Date: 2024-01-10 20:51:27
Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-Methyl-2-propanyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate
Synonyms	7,10,13,16-Tetraoxa-2,3-diazaoctadecan-1-oic acid, 18-amino-4-oxo-, 1,1-dimethylethyl ester 2-Methyl-2-propanyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate

Description	Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562