153050-21-6

153050-21-6 structure

Name: SR 140333
Chemical Name: 22O6ξ63E0
CAS Number: 153050-21-6
Molecular Formula: C₃₇H₄₅Cl₃N₂O₂
Molecular Weight: 656.12
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-07-10 03:27:26
Modify Date: 2024-01-14 10:15:03
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].

Name	22O6ξ63E0
Synonyms	1-Azoniabicyclo[2.2.2]octane, 1-[2-[(3S)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-, chloride (1:1) 22O6ξ63E0 1-(2-{(3S)-3-(3,4-Dichlorophenyl)-1-[(3-isopropoxyphenyl)acetyl]-3-piperidinyl}ethyl)-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride 1-{2-[(3S)-3-(3,4-dichlorophenyl)-1-{[3-(propan-2-yloxy)phenyl]acetyl}piperidin-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride NOLPITANTIUM CHLORIDE

Description	Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK1
References	[1]. Emonds-Alt X, et al. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.