1222097-72-4

1222097-72-4 structure

Name: S38093 HCl
Chemical Name: s38093
CAS Number: 1222097-72-4
Molecular Formula: C₁₇H₂₅ClN₂O₂
Molecular Weight: 324.85
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-07-13 17:04:50
Modify Date: 2024-03-06 11:19:46
S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.

Name	s38093
Synonyms	4-[3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy]benzamide hydrochloride (1:1) Benzamide, 4-[3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy]-, hydrochloride (1:1)

Description	S 38093 hydrochloride is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. [2]. Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23