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1334177-81-9

1334177-81-9 structure
1334177-81-9 structure
  • Name: S-Acetyl-PEG8-OH
  • Chemical Name: S-acetyl-PEG8 alcohol
  • CAS Number: 1334177-81-9
  • Molecular Formula: C18H36O9S
  • Molecular Weight: 428.538
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-23 05:28:57
  • Modify Date: 2024-01-08 18:47:57
  • S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name S-acetyl-PEG8 alcohol
Synonyms MFCD13185027
Ethanethioic acid, S-(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ester
S-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl) ethanethioate
Description S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 512.3±50.0 °C at 760 mmHg
Molecular Formula C18H36O9S
Molecular Weight 428.538
Flash Point 263.6±30.1 °C
Exact Mass 428.208008
LogP -2.13
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.478