DC Chemicals Limited
China
Product Name: Tyroserleutide (YSL)
Price: $400.0/10mg $650.0/25mg $950.0/50mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

138168-48-6

138168-48-6 structure

138168-48-6 structure

Name: Tyroserleutide (YSL)
Chemical Name: Tyroserleutide
CAS Number: 138168-48-6
Molecular Formula: C₁₈H₂₇N₃O₆
Molecular Weight: 381.423
Catalog: Research Areas Cancer
Create Date: 2019-01-02 09:17:05
Modify Date: 2024-01-02 13:37:25
Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].

Name	Tyroserleutide
Synonyms	L-Tyrosyl-L-seryl-L-leucine L-Leucine, L-tyrosyl-L-seryl-

Description	Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Antitumor tripeptide[1][2]
In Vitro	Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1]. Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2]. Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2]. Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2].
In Vivo	Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1]. Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1] Dosage: 10, 20, 40, and 80 μg/kg Administration: Injection (i.p.) one time every day until mice were dead. Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively.
References	[1]. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95. [2]. Liang P, et al. pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy. Adv Healthc Mater. 2019 Aug;8(15):e1900306.

Density	1.3±0.1 g/cm3
Boiling Point	763.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₇N₃O₆
Molecular Weight	381.423
Flash Point	415.7±32.9 °C
Exact Mass	381.189972
LogP	0.89
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.577