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1589522-46-2

1589522-46-2 structure
1589522-46-2 structure
  • Name: Propargyl-PEG5-amine
  • Chemical Name: Propargyl-PEG5-amine
  • CAS Number: 1589522-46-2
  • Molecular Formula: C13H25NO5
  • Molecular Weight: 275.341
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-07-05 01:46:21
  • Modify Date: 2025-08-27 12:01:23
  • Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name Propargyl-PEG5-amine
Synonyms PROPARGYL-PEG5-NH2
Description Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.

Density 1.0±0.1 g/cm3
Boiling Point 360.4±37.0 °C at 760 mmHg
Molecular Formula C13H25NO5
Molecular Weight 275.341
Flash Point 166.5±20.2 °C
Exact Mass 275.173279
LogP -1.54
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.464
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