1802908-05-9

1802908-05-9 structure

Name: Methyltetrazine-PEG4-amine HCl
Chemical Name: Methyltetrazine-PEG4-Amine
CAS Number: 1802908-05-9
Molecular Formula: C₁₇H₂₅N₅O₄
Molecular Weight: 363.411
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-14 22:54:36
Modify Date: 2024-01-02 17:58:11
Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Methyltetrazine-PEG4-Amine
Synonyms	2-[2-(2-{2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy}ethoxy)ethoxy]ethanamine Ethanamine, 2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]- MFCD28334553

Description	Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562