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1807512-43-1

1807512-43-1 structure
1807512-43-1 structure
  • Name: Dde Biotin-PEG4-DBCO
  • Chemical Name: Dde Biotin-PEG4-DBCO
  • CAS Number: 1807512-43-1
  • Molecular Formula: C47H61N5O9S
  • Molecular Weight: 872.080
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-12 13:14:40
  • Modify Date: 2024-01-10 09:32:13
  • Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Dde Biotin-PEG4-DBCO
Synonyms 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
MFCD28505548
N-[19-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Description Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.3±0.1 g/cm3
Boiling Point 1103.9±65.0 °C at 760 mmHg
Molecular Formula C47H61N5O9S
Molecular Weight 872.080
Flash Point 621.4±34.3 °C
Exact Mass 871.419006
LogP 3.80
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.620
Storage condition -20°C