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1807530-06-8

1807530-06-8 structure
1807530-06-8 structure
  • Name: Azido-PEG1-NHS ester
  • Chemical Name: Azido-PEG1-NHS ester
  • CAS Number: 1807530-06-8
  • Molecular Formula: C9H12N4O5
  • Molecular Weight: 256.215
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-05 17:24:28
  • Modify Date: 2024-01-12 08:15:42
  • Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Azido-PEG1-NHS ester
Synonyms 1-{[3-(2-Azidoethoxy)propanoyl]oxy}-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[3-(2-azidoethoxy)-1-oxopropoxy]-
MFCD26793773
Description Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C9H12N4O5
Molecular Weight 256.215
Exact Mass 256.080780
LogP -1.51