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1818294-26-6

1818294-26-6 structure
1818294-26-6 structure
  • Name: S-acetyl-PEG4-Boc
  • Chemical Name: S-acetyl-PEG4-t-butyl ester
  • CAS Number: 1818294-26-6
  • Molecular Formula: C17H32O7S
  • Molecular Weight: 380.497
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-07 00:23:10
  • Modify Date: 2024-01-10 18:53:51
  • S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name S-acetyl-PEG4-t-butyl ester
Synonyms 2-Methyl-2-propanyl 2-oxo-6,9,12,15-tetraoxa-3-thiaoctadecan-18-oate
MFCD22574785
6,9,12,15-Tetraoxa-3-thiaoctadecan-18-oic acid, 2-oxo-, 1,1-dimethylethyl ester
Description S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 452.0±40.0 °C at 760 mmHg
Molecular Formula C17H32O7S
Molecular Weight 380.497
Flash Point 207.2±15.4 °C
Exact Mass 380.186859
LogP 1.16
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.471