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1818294-35-7

1818294-35-7 structure
1818294-35-7 structure
  • Name: Fluorescein-PEG6- NHS ester
  • Chemical Name: Fluorescein-PEG6-NHS ester
  • CAS Number: 1818294-35-7
  • Molecular Formula: C40H45N3O15S
  • Molecular Weight: 839.861
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-18 00:06:51
  • Modify Date: 2024-01-11 13:11:00
  • Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Fluorescein-PEG6-NHS ester
Synonyms 5-[({21-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
Benzoic acid, 5-[[23-[(2,5-dioxo-1-pyrrolidinyl)oxy]-23-oxo-1-thioxo-5,8,11,14,17,20-hexaoxa-2-azatricos-1-yl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
MFCD23726632
Description Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.5±0.1 g/cm3
Boiling Point 976.2±75.0 °C at 760 mmHg
Molecular Formula C40H45N3O15S
Molecular Weight 839.861
Flash Point 544.2±37.1 °C
Exact Mass 839.257141
LogP -1.08
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.649