1146195-72-3

1146195-72-3 structure

Name: Fluorescein-thiourea-PEG2-azide
Chemical Name: Fluorescein-PEG2-Azide
CAS Number: 1146195-72-3
Molecular Formula: C₂₇H₂₅N₅O₇S
Molecular Weight: 563.582
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-02 19:24:16
Modify Date: 2025-08-26 23:32:16
Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Fluorescein-PEG2-Azide
Synonyms	MFCD23726635 Benzoic acid, 5-[[[[2-[2-(2-azidoethoxy)ethoxy]ethyl]amino]thioxomethyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)- 5-[({2-[2-(2-Azidoethoxy)ethoxy]ethyl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

Description	Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562