1282040-14-5

1282040-14-5 structure

Name: 3'-Azido-3'-deoxy-5-methylcytidine
Chemical Name: 3'-Azido-3'-deoxy-5-methylcytidine
CAS Number: 1282040-14-5
Molecular Formula: C₁₀H₁₄N₆O₄
Molecular Weight: 282.26
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-06-23 08:44:04
Modify Date: 2024-01-02 12:01:05
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1].

Name	3'-Azido-3'-deoxy-5-methylcytidine

Description	3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	HIV-1:0.06 μM (EC50, in PBM cells) XMRV:43.5 μM (CC50, in MCF-7 cells)
References	[1]. Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.