1333154-70-3

1333154-70-3 structure

Name: NHS-PEG4-(m-PEG4)3-ester
Chemical Name: NHS-PEG4-(m-PEG4)3-ester
CAS Number: 1333154-70-3
Molecular Formula: C₆₀H₁₁₀N₆O₂₈
Molecular Weight: 1363.539
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-06 09:19:25
Modify Date: 2024-01-08 18:55:23
NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	NHS-PEG4-(m-PEG4)3-ester
Synonyms	4,11,14,17,20-Pentaoxa-7,23-diazaoctacosan-1-amide, 28-[(2,5-dioxo-1-pyrrolidinyl)oxy]-8,24,28-trioxo-6,6-bis(5-oxo-2,9,12,15,18-pentaoxa-6-azanonadec-1-yl)-N-3,6,9,12-tetraoxatridec-1-yl- MFCD22683277 28-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-8,24,28-trioxo-6,6-bis(15-oxo-2,5,8,11,18-pentaoxa-14-azanonadecan-19-yl)-N-(2,5,8,11-tetraoxatridecan-13-yl)-4,11,14,17,20-pentaoxa-7,23-diazaoctacosan-1-amide

Description	NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562